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    Soon after valeant took over, it doubled addyis price and planned to sell it to patients through a mail-order pharmacy, philidor rx services. One was viking global investors, a hedge fund with 45 billion under management. Valeant also halted a planned speakers program, in which doctors explained the drug to their colleagues.

    Six former sprout employees said the money helped pay for two national sales directors, including one who had sold viagra when it went on sale in 1998. He left the room a few minutes later, in spite of having promised to stay for the day. Former sprout employees say that the changes in marketing strategy complicated their efforts to sell doctors on the pill.

    Now sprout shareholders, in their letter to valeant, say that relying on philidor to distribute addyi was a crucial mistake. Interviews with former sprout employees, analysts, investors and doctors who helped bring the drug to market suggest how a series of missteps after the deal, along with turbulence from aggressive accounting practices, unusual business relationships and big egos, derailed one of the most intriguing new pharmaceuticals in a generation. And a vocal investment research firm that had bet against valeants shares published a report criticizing the companys accounting.

    Ackman, the hedge fund manager and one of valeants biggest backers. The valeant spokeswoman said the company intended to fulfill its obligations under the deal. That didnt work, but some early clinical trials did show an increase in sex drive among women.

    Still, even with the roadblocks, some analysts predicted that millions of women would take the drug. Cvscaremark, the pharmacy benefits manager, notified valeant several weeks before the pills introduction that it would not cover addyi at the 800 price, according to a letter sprout shareholders sent to valeant in march. The multiple restrictions blunted some of the excitement around the drugs approval, said dr.

    Simon, a member of valeants scientific advisory board for addyi, said the company seemed out of its depth. Ackman also bought a personal stake in sprout in june 2015, two months before its drug was approved by the f. Valeants purchase of sprout turned out to be a colossal failure, said vicki bryan, an analyst at gimme credit, a debt analysis firm. They also say they did not have access to many of their standard sales tools, including basic promotional materials like wall posters and brochures. Sure enough, after the drug was approved, anthem, one of the nations largest insurers, said it would cover the drug at the 400 price.


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    Simon, a member of valeants scientific advisory board for addyi, said the company seemed out of its depth. And viagra, which can lead to side effects like dizziness and nausea, does not carry a black-box warning. On wednesday, in a call with pershing square investors, mr. Today, as addyi struggles, valeants broader difficulties could limit its ability to invest in the drugs marketing effort. Pearson took the stage, he forgot the names of the patients who had just spoken.

    Cvscaremark, the pharmacy benefits manager, notified valeant several weeks before the pills introduction that it would not cover addyi at the 800 price, according to a letter sprout shareholders sent to valeant in march. In their letter to valeant, angry sprout shareholders asked the company to explain its actions. It need only be taken before sex, not daily like addyi. Despite the optimism, addyi (pronounced add-ee) was never going to be an easy sell. Simon, who served as the chief medical officer at sprout from 2012 to 2013.

    In clinical trials, women taking the pink pill reported having about one more sexually satisfying experience per month than those taking a placebo. Six former sprout employees said the money helped pay for two national sales directors, including one who had sold viagra when it went on sale in 1998. Wood, an associate professor of health policy at george washington university, who opposed the drugs approval. Valeant has acknowledged that sales of addyi have not lived up to expectations and that it plans to invest more in the drug. Ackmans comments, but clearly, recouping the 1 billion the company paid for addyi will take some time. And a vocal investment research firm that had bet against valeants shares published a report criticizing the companys accounting. Within weeks of the deal, valeant went from investor idol to pariah as its business model of buying older drugs and raising the prices attracted international scorn. Ackman, the hedge fund manager and one of valeants biggest backers. On monday, valeant dismissed the entire sales force behind the drug and said it planned to reintroduce addyi this year. In clinical trials, women reported a small, but statistically significant, uptick in the number of satisfying sexual experiences per month.

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